Phytochemical screening and insilico approach for identification of anti stress activity of compounds from medicinal plants

Ayurvedha and Herbal medicine are two important forms of alternative medicine that are widely available. Medicinal plants have disease curing properties and this is due to the compounds presents in the extracts. This work is mainly concerned with the identification of the therapeutic properties of Indian medicinal plant extracts. So we identified the compounds of different medicinal plants like Celastrus paniculatus, Withania somnifera, Convolvulus pluricaulis, Rauvoifia Serpentina etc which are used as medicine for Stress in Ayurvedha from previous literature. Using chemsketch software these compounds were designed and screened for antistress property. The proteins responsible for stress in Homo sapiens were collected using Protein databank (PDB). Then the compounds were docked to the Calcium channel active site in order find better inhibitor. Among 33 compounds 10 compounds showed best docking results. ADMET studies were performed using Molinspiration and OSIRIS server.